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Dr. Miriam Shephard is introduced in A Discovery of Witches as a lab colleague of Matthew Clairmont. Miriam is also responsible for the computer security system in the lab. Miriam is described as initially irritable, disapproving, catty and unfriendly, but she ultimately accepts Diana. Miriam resents that her husband was executed as a scapegoat during the time of the Saracens, and blames Matthew. Miriam is petite, with dark eyes and flat black curls. She can move unusually quickly and enjoys film noir.

She helps Matthew protect Diana Bishop from creatures in the library after Diana discovers Ashmole 782. She also helps save Diana's life when a vampire attacks Diana. She tells Matthew to stop fussing at her while she is attending to Diana, as she was doing this long before he was reborn.